The Alzheimer's Disease It is one of the greatest mysteries of medicine. And while researchers are trying to find their causes, this is Neurodegenerative disease, currently without treatment, is the fifth cause of death in the world, since the population lives longer, its effect increases. Among the new hypotheses, one study published a alarm idea: Alzheimer's can be an infection.
Although the perspective is not new, it is the pA concrete area that offers a specific type of bacteria: Porphyromonas gingivalis, The Gram-negative cocoa that causes Chronic periodontitis, or gingivitis.
The microbiologist Jan Potempa, from the University of Louisville, led team that found that bacteria in the brain of patients who died of Alzheimer's. And to check the relationship between her and the illness, they did Experiments in mice, in which they found that oral infections with this bacillus increased the production of beta-amyloid, the protein often associated with Alzheimer's.
In the investigation he participated Stephen Dominy, co-founder of the start Top. The pharmacy company fulfills Clinical drug studies that could prevent the proliferation of the toxins of the drug P. gingivilis. Depending on its efficiency, a treatment, and even vaccine, against the bacteria; which is not equivalent to a vaccine against Alzheimer's, but would open an important way to explore therapies.
"Previously, infectious agents were linked to the development and progress of Alzheimer's, but the evidence of a cause was not convincing, "said Dominy. Science Warning. "Now, For the first time, we have a solid evidence that connects the intracellular pathogen, the gram-negative bacillus P. gigivalis, and the pathological origin of Alzheimer's"
In addition, the team was in the brain of patients killed by the disease toxic enzymes that the bacteria separate, called Gingipainas, in relation to two independent markers of evil, the Tau protein and ubiquitine protein marker.
When examining brains of people who did not suffer Alzheimer's before their death, scientists found lower levels of P. gingivalis, which could be a warning signal: if they had lived longer, they could have developed the disease.
"Identification of gypsum in the brain of individuals diagnosed with Alzheimer's, and also with the pathology even if they have not been diagnosed, suggests that the brain infection with P. gingivalis It is not the result of poor dental health taken care of due to the dementia start, not a consequence of the final stages of the disease, but early manifestation, "they wrote in the paper.
The study also tried the drug developed by Cortexyme, called COR388, which is currently in clinical tests with Alzheimer's patients. When used in mice, it showed its ability reduce the amount of bacteria in brain infection P. gingivalis, while reducing beta-amyloid production and tissue inflammation.
However, "the The drugs against the toxic proteins of bacteria have only shown benefits in mice, to date"said David Reynolds, scientific director of Alzheimer's Research." But give that For more than 15 years there is no new treatment for dementiaIt is important that we try as many accesses as possible to stop illnesses such as Alzheimer's. "
The evil is usually distinguished by the accumulation of amiloid and tau proteins in the brain that proliferates and can be solved for 10 or even 20 years before you notice the symptoms. And while it is possible to have plastics amiloids without suffering dementia, scientists have tried to control them during the search for treatment. It calculates that These proteins are a defense against bacteria that will open a new way to their control: eliminate the microorganism that causes them.
The P. gingivalis not only causes gingivitis: it has also been proven to be Risky factor for inflammatory system diseases, pulmonary infections, myocardial infarct, arteriosclerosis and the feeding preview.