A team of researchers from the University of Cincinnati (UC) College of Medicine has been awarded $ 3.4 million by the National Institutes of Health (NIH) to investigate the role of gastrointestinal tract (GI) in nutrient uptake and signaling of molecules.
The lymphatic system is a network of blood vessel channels that allow the return of colorless liquids in the lymph nodes, which contain white blood cells that wash the tissue and drain the lymphatic system into the bloodstream, back into the bloodstream. In the gastrointestinal tract, lymphatic flow has an additional function of transporting triglycerides rich in chylomicrons, various hormones and signaling molecules secreted by the cells of the gastrointestinal tract.
"Compared to other cardiovascular systems, we now have a relatively poor understanding of the physiological significance of the lymphatic system, which is essential for the proper functioning of the gastrointestinal tract and overall metabolic health," said Patrick Tasso, Ph.D., Professor and Mary M. , Dr. Yvonne Ulrich-Lay, Doctor of Philosophy and Physiology Systems, and Mayo Liu, Professor of Pathology and Laboratory Medicine, are major researchers in the study.
The GI lymphatic system, says Tso, may turn out to be a critical area of research relevant to diabetes.
For example, he says that when patients undergo bariatric surgery, in most cases, their diabetes turns over quickly, long before they begin to lose weight. Ulrich-Lai, Liu, and Tso believe that disruption of the lymphatic circulation may be involved in this interesting clinical finding.
In this study, the researchers created a similar disruption of drainage of the lymphatic system in an animal model to assess its effect on metabolic health.
"We hope to shed light on the mechanism involved in making diabetes through bariatric surgery," says Tso.
Tsu joined the Department of Pathology and Laboratory Medicine at the University of California College of Medicine in 1996 as a professor of pathology and associate in the Department of Physiology. Tsu's career there included roles as Associate Director of the Center for Obesity Research; Director of the NIH-funded Cincinnati Mouse Metabolic Phenotyping Center and director of the Center for Lipid Research. In 2010, he received the Daniel Drake Medal, the highest honor given to the Faculty of Medicine.
Five years, $ 3.4 million, a grant comes from the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) (1RO1DK119135-01).
The authors do not indicate a conflict of interests.
Provided by the University of Cincinnati Center for Academic Health
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