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"The findings of this study go further than many previous ones," he says Christoph Steininger from Vienna MedUni: US researchers have come up with a mechanism to find out why a high fat diet leads to obesity – and that has more to do with more than just the amount of calories.
The so-called "intestinal brain axis" comes into play: The high-fat-fed mice produced in the intestine have increased amounts of hormone (GDP), which plays a role in metabolism. This over-produced hormone increased the high-fat mice fatty blood. in the brain – and had an unexpected effect there:
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