On Friday, Murray announced he would return to single action for the first time since January after receiving a wild card from the organizing tournaments.
And the British star will open his campaign against Frenchman Richard Gasquet.
If Murray goes through that match, he will face world No 4 Dominic Thiem in the second round.
The top eight seeds say goodbye in the first round and it means that Novak Djokovic will start his title defense against Sam Querrey or Pierre-Hugues Herbert in the second round.
Roger Federer will play the winner of Matteo Berrettini and Juan Ignacio Londero.
And if Rafael Nadal decides to play in Ohio, he will open his campaign against either Cristian Garin or Adrian Mannarino.
If Djokovic and Federer come through their section of the draw, they are projected to meet in the semi-finals.
Notable first-round matches include Stan Wawrinka vs Grigor Dimitrov and Gael Monfils vs Frances Tiafoe.
PROJECTED CINCINNATI MASTERS FOUR-ENDS
1 Djokovic vs. 8 Khachanov
3 Federer vs 6 Tsitsipas
5 Zverev vs 4 Thiem
7 Nishikori vs 2 Christmas