Saturday , June 19 2021

HIV type 2 is more severe than expected



HIV is a mutated virus originally derived from chimpanzees. It must have been passed on to people through the cursed meat the hunters brought to the villages. One of the mutations became a feared virus that spread throughout the world.

HIV and AIDS

HIV is a virus that destroys the immune system. If the infection is not treated, the immune system will eventually weaken to get AIDS. Aids are defined as blue that receives certain severe infections or special cancers. Fortunately, there are drugs that can keep the AIDS virus at risk and the risk of infection is small.

But there is also another type of HIV called HIV type 2. This virus probably originated from another monkey, Mengbi sooty. HIV-2 is hardly found in the West, but has spread in West Africa. This virus is less contagious.

Researchers from the University of Lund in Sweden have been monitoring all police in Guinea-Bissau in a small country since 1990. Researchers continued to recruit police officers by 2009 and complete data collection in 2013. Out of a total of 4,700 people, 408 were infected with HIV-1 and – 464 infected with HIV-2.

The researchers continued to develop the disease.

– The strength of this study is a very long and meritorious follow-up of many patients relatively large area, writes Dag Kvale e-mail to forskning.no. He is a professor and director of the Department of Infection at the University Hospital of Oslo (OUS). Kvale is not even identified with Swedish research.

– Need clearer recommendations

Data collection done prior to Guinea-Bissau had access to ART drugs that inhibited the infection. Those infected with HIV-1 developed AIDS after an average of 6.2 years. While those receiving HIV-2 developed AIDS after 14.3 years.

Earlier studies have shown that those infected with HIV-2 should live as long as possible. But many of those in this group have developed and died of AIDS, the researchers write. The development of the disease occurred more slowly in HIV-2 infected, but otherwise the course was similar.

"This is a perception in research and health in the world that HIV-2 does not lead to disease in the same way as HIV-1." We will break the myth to change the landscape of international treatment recommendations, "says Hans Norgren, general practitioner at the University Hospital of Skane, On the findings.

Dag Kvale at Oslo University Hospital Hise says that it is known that HIV-2 is also a pathogen like HIV-1, but development is significantly slow.

– As such, this study is affirmative. HIV-2 has low propagation potential; I only passed 2 to 30 years ago. Nearly 200 were found in the United States by 2009, possibly with some dark numbers. Therefore, we know that if HIV-2 succeeds in infecting someone, patients receive approximately 1/30 of the virus in the blood compared to HIV-1. This probably explains both slow progress and a low rate of infection, Kvale says.

"The significance of this study may be a slightly more" aggressive "treatment of HIV-2 if you see patients at all, but only a selection of our common HIV drugs is effective against this type. HIV-2.

Joakim Asborenson, one of the researchers behind the study, believes that more clear recommendations for initiating early treatment in patients diagnosed with HIV-2 in West Africa and elsewhere should be seen.

Reference:

Joakin Esbjörnsson et al.: Long-term monitoring of HIV-2 related to AIDS and Guinea-Bissau mortality: An open fur study, Lancet generation, November 2018


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