Thursday , June 17 2021

Memory loss caused by Alzheimer's can be restored: Study



Alzheimer's Disease

Memory loss caused by Alzheimer's can be restored: Study & nbsp & nbspPhoto Credit: & nbspTink

New York City: Researchers have developed a new focus, which maybe one day it is possible to reverse memory, caused by Alzheimer's disease.

The team, headed by a University at Bubalo scientists, found that focusing on the genetic changes caused by influences, apart from the sequences of DNA, called epigenetics – was able to reverse a recession in Alzheimer's animal model.

"We have not only identified the epigenetic factors that contribute to the memory, but we also found ways to reverse them into an Alzheimer's animal model," said Zhen Yan, a professor at the University of Buffalo in the United States.

The research, published in the Brain magazine, was made on muscle models bearing genuine mutations for family Alzheimer's, with more than one family member having the disease and on post-mortem-brain fabrics of Alzheimer's patients.

Alzheimer's is caused by both genetic and ecological risk factors, such as aging, which combines epigenetic changes, leading to genuine expressions of changes, but little know about it.

The epigenetic changes in Alzheimer's occur mainly in the later stages, when patients can not retain recently learned information and show the most dramatic cognitive decline, said Yan. A key reason for cognitive decline is the loss of glutamous receptors, which are critical for learning and in recent memory.

The researchers found that the loss of glutamous receptors is the result of an epigenetic process known as a repressive histone modification that is raised in Alzheimer's.

"Our study not only reveals the relationship between epigenetic changes and Alzheimer's, we may also be able to correct cognitive dysfunction by targeting the epigenetic enzymes to restore glutamate receptacles," said Yan. Alzheimer's animals were injected three times with compounds designed to stop the enzyme that controls repressive histone modification.

In animals that have received the enzyme inhibitor, the cognitive function has restored and has been confirmed by estimation of memory recognition, space memory and work memory.

The improvements lasted for a week. Future studies will focus on developing compounds that more effectively penetrate the brain and are so persistent, the researchers said.


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